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<br>Issue date 2021 May. To realize highly accelerated sub-millimeter decision T2-weighted functional MRI at 7T by developing a three-dimensional gradient and spin echo imaging (GRASE) with inner-quantity selection and variable flip angles (VFA). GRASE imaging has disadvantages in that 1) ok-space modulation causes T2 blurring by limiting the variety of slices and 2) a VFA scheme leads to partial success with substantial SNR loss. In this work, accelerated GRASE with managed T2 blurring is developed to improve a point spread operate (PSF) and temporal sign-to-noise ratio (tSNR) with numerous slices. Numerical and BloodVitals SPO2 experimental studies were performed to validate the effectiveness of the proposed method over regular and BloodVitals SPO2 VFA GRASE (R- and V-GRASE). The proposed method, while achieving 0.8mm isotropic decision, useful MRI compared to R- and V-GRASE improves the spatial extent of the excited volume up to 36 slices with 52% to 68% full width at half maximum (FWHM) discount in PSF but approximately 2- to 3-fold mean tSNR enchancment, thus resulting in larger Bold activations.<br> |
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<br>We successfully demonstrated the feasibility of the proposed method in T2-weighted practical MRI. The proposed methodology is especially promising for cortical layer-specific functional MRI. For the reason that introduction of blood oxygen level dependent (Bold) distinction (1, 2), practical MRI (fMRI) has grow to be one of the most commonly used methodologies for neuroscience. 6-9), wherein Bold effects originating from bigger diameter draining veins can be significantly distant from the precise sites of neuronal activity. |
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